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  • Title: Comparison of the virulence for mice of Mycobacterium avium and Mycobacterium intracellulare identified by DNA probe test.
    Author: Tomioka H, Saito H, Sato K, Dawson DJ.
    Journal: Microbiol Immunol; 1993; 37(4):259-64. PubMed ID: 8350768.
    Abstract:
    The virulence of various serovars of Mycobacterium avium and M. intracellulare identified by DNA probe test was compared with each other. We found species- and serovar-dependencies of M. avium complex (MAC) virulence to mice in terms of mortality, incidence of lung lesions and bacterial load in the visceral organs, as follows. First, human- or environment-derived M. intracellulare was more virulent for mice, as compared to M. avium isolated from patients or environmental sources. Second, the virulence of MAC isolates belonging to serovars 1, 8, 9 (M. avium), 14 and 16 (M. intracellulare) is in the order of serovars 16 > 14 > 8 > 1 > 9. These aspects were different from those for MAC virulence to human and bird, swine and cattle.
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