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  • Title: Circulating immune complexes in Hodgkin's disease. Reactivity of IgG isolated from circulating immune complexes.
    Author: Nerurkar AV, Advani SH, Gothoskar BP.
    Journal: Neoplasma; 1993; 40(2):87-91. PubMed ID: 8350960.
    Abstract:
    In our earlier report on circulating immune complexes (CIC) from sera of patients with Hodgkin's disease (HD), we demonstrated disease-associated increase in the intensity of a 40kD (pl 5.6) polypeptide in the CIC. In extension of these investigations, we now report that the 40kD moiety exists in CIC as a complex with IgG, and that IgG isolated from such CIC samples from sera of patients with HD shows preferential reactivity with the typical large binucleate Reed-Sternberg (R-S) cells in the sections of disease-involved lymph nodes from HD patients.
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