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  • Title: Reserpine and cerebral vasospasm.
    Author: Watts C.
    Journal: Stroke; 1977; 8(1):112-4. PubMed ID: 835151.
    Abstract:
    Cerebral vasospasm was produced in the dog basilar artery by topically applied five-day-old clotted autologous blood, but not by freshly drawn blood. The spasm was reversed by methysergide, an antiserotonin agent. However, vasospasm was not produced by five-day-old clotted autologous blood from dogs pretreated with reserpine. This suggests platelet serotonin or a similar, unidentified substance as the vasospastic element in dog blood responsible for experimental vasospasm from topically applied whole blood. Other experimental data support these findings.
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