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  • Title: [Thrombolytic effect of plasmin, miniplasmin and fibrinolysin in simulated intraocular hemorrhage].
    Author: Metelitsyna IP, Petretskaia OS, Rodin SS, Andrianov SI.
    Journal: Ukr Biokhim Zh (1978); 1993; 65(1):93-7. PubMed ID: 8351749.
    Abstract:
    The fibrinolytic properties of the preparations of plasmin (Pm), mixture of plasminogen and streptokinase (Pg+Sk), miniplasmin (m-Pm) and fibrinolysin have been investigated on the models of rabbit's hyphema. The action of preparations of Pm and Pg+Sk had approximately equal therapeutic index--the total destruction of clots proceeded for 12.0 days, that was 6.6 days less than in the control group. The therapeutic effect for m-Pm was 3.6 days. The dose of preparation of m-Pm, necessary for total destruction of clots, was 15-20% greater than for the same dose of Pg+Sk. The preparation of fibrinolysin, used in the same quantities of proteolytic activity, as Pg and m-Pg, (16 caseinolytic units per 1 injection) had no therapeutic effect.
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