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  • Title: Effects of tetrahydroberberine on ischemic and reperfused myocardium in rats.
    Author: Zhou J, Xuan B, Li DX.
    Journal: Zhongguo Yao Li Xue Bao; 1993 Mar; 14(2):130-3. PubMed ID: 8352004.
    Abstract:
    The effects of tetrahydroberberine (THB) on ischemic and reperfused myocardium were studied in comparison with verapamil (Ver). In anesthetized rats, THB and its analogues, l-THP and l-SPD, reduced the infarct size after 4 h of left anterior descending coronary artery (LAD) ligation. In Langendorff hearts, in common with Ver, THB 1 and 10 mumol.L-1 markedly decreased the incidences of ventricular tachycardia (VT) and ventricular fibrillation (VF) in the reperfusion period. The malondialdehyde content and xanthine oxidase activity were also decreased in global ischemic-reperfused hearts pretreated with THB (P < 0.01, or P < 0.05). It suggested that THB could protect the myocardium from ischemic and reperfusion injury.
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