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  • Title: Role of N-6 and N-3 fatty acids in the dietary treatment of metabolic disorders.
    Author: Collier GR, Sinclair AJ.
    Journal: Ann N Y Acad Sci; 1993 Jun 14; 683():322-30. PubMed ID: 8352454.
    Abstract:
    The impetus to examine the effects on n-3 PUFA was generated from epidemiologic studies of a traditional population largely dependent on the marine environment. These studies and clinical interventions support a recommendation to increase the consumption of n-3 fatty acids, particularly in communities that currently have a low n-3 fatty acid intake. If we are to be guided by the diet of other traditional hunter-gatherer populations, dependent on both terrestrial and marine sources of food, it is clear that we may need to reappraise the importance of long chain PUFA of the n-6 series such as arachidonic acid. Recent studies on such populations indicate that elevated arachidonic acid levels, when associated with elevated n-3 PUFA, are likely not to be harmful to health.
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