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  • Title: Up-regulation of ETB receptor subtype mRNA by angiotensin II in rat cardiomyocytes.
    Author: Kanno K, Hirata Y, Tsujino M, Imai T, Shichiri M, Ito H, Marumo F.
    Journal: Biochem Biophys Res Commun; 1993 Aug 16; 194(3):1282-7. PubMed ID: 8352786.
    Abstract:
    The effect of angiotensin (ANG) II on the expression of endothelin (ET) receptor subtype (ETA, ETB) mRNA in cultured neonatal rat cardiomyocytes was studied. ANG II (10(-7) M) increased steady-state mRNA levels of ETB receptor, but not ETA receptor, during 6-12 hr incubation, whose effect was dose-dependent (10(-9)-10(-7) M). ANG II receptor type-1 (AT1) antagonist (CV-11974) completely inhibited the ANG II-induced up-regulation of ETB receptor, whereas the inhibitory effect by ANG II receptor type-2 (AT2) antagonist (PD 123319) was incomplete. These results suggest that ANG II up-regulates cardiac ETB receptor, predominantly via AT1 receptor.
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