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  • Title: Synthesis and antimalarial activity of some 9-substituted artemisinin derivatives.
    Author: Acton N, Karle JM, Miller RE.
    Journal: J Med Chem; 1993 Aug 20; 36(17):2552-7. PubMed ID: 8355254.
    Abstract:
    Several 9-substituted derivatives of the antimalarial drug artemisinin have been prepared by functionalizing the double bond of artemisitene and related compounds. Stereochemical assignments for these compounds were made using a combination of NMR experiments, an X-ray diffraction study of one compound, and chemical correlations of several other compounds with this one compound of unambiguous structure and with its epimer. The compounds synthesized show a wide variation in in vitro antimalarial activity.
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