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  • Title: [Infection and systemic lupus erythematosus: analysis of a series of 145 patients].
    Author: Formiga Pérez F, Moga Sampere I, Canet González R, Pac Ferraz M, Mitjavila Villero F, Fernández Nogués F.
    Journal: Rev Clin Esp; 1993 Jul; 193(3):105-9. PubMed ID: 8356286.
    Abstract:
    Systemic lupus erythematosus (SEL) is a chronic inflammatory disease, which often requires corticosteroid treatment, being infection a common cause of both morbidity and mortality. We report the infectious episodes from 145 SLE patients revisited through 1975-1991, with a 6.8 years mean follow-up period. The relationship between each episode and several variables, especially corticosteroid treatment a month before the infectious episode, was analyzed. Forty two infections were diagnosed in 32 patients (22.06%). A significant increase in the number of infections among SLE patients with daily corticosteroids treatment was observed with respect to that of SLE patients with alternate day treatment (p < 0.001). The administration corticosteroids in alternate day form, if possible, can decrease the infection incidence in SLE patients.
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