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  • Title: [Recombinant granulocyte colony-stimulating factor in the long-term treatment of AIDS-related neutropenias].
    Author: Garavelli PL, Berti P.
    Journal: Recenti Prog Med; 1993; 84(7-8):526-30. PubMed ID: 8356307.
    Abstract:
    Neutropenia is a common finding in patients with AIDS or AIDS-related complex (ARC), and limits their survival and therapies. We administered recombinant human granulocyte colony-stimulating factor (rG-CSF) 300 micrograms/day to 15 AIDS patients with severe neutropenia (< 1000/microliters). without discontinuing zidovudine, ganciclovir or other myelosuppressive drugs (e.g. antineoplastic chemotherapy). All patients showed correction of neutropenia and/or limitation of drug myelosuppressive action. Neutrophil count was > 1000/microliters during the whole follow-up (11 months). No patient showed sepsis, opportunistic infections or side effects. These data confirm the efficacy and tolerability of rG-CSF in AIDS-related neutropenia.
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