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  • Title: Prognostic factor of radiotherapy for squamous cell carcinoma of oropharynx without clinically positive nodes.
    Author: Inoue T, Inoue T, Ikeda H, Teshima T, Murayama S, Yamazaki H, Otani M.
    Journal: Strahlenther Onkol; 1993 Aug; 169(8):476-80. PubMed ID: 8356506.
    Abstract:
    Local control rates of oropharynx carcinoma treated with radiation alone were reported as 40 to 71%. We investigate the factors which affect the local control rate for oropharynx carcinoma. From 1967 through 1982, 62 cases of squamous cell carcinoma of oropharynx without positive neck nodes were treated with external radiation at the Department of Radiology, Osaka University Hospital. Five-year actuarial survival rates of T1, T2, T3 and T4 cases were 53%, 63%, 47% and 0%, respectively. Five-year local control rates of T1, T2, T3 and T4 cases were 51%, 46%, 34% and 0%, respectively. In 52 cases treated with a total dose of 60 Gy or more, tumor response could be evaluated at the dose level of 40 and 60 Gy. The local control rates of tumors which disappeared and persisted at 40 Gy were 88% (7/8) and 39% (17/44), respectively (p < 0.05). Of 44 cases which persisted at 40 Gy, the local control rates of tumors which disappeared and persisted at 60 Gy were 48% (11/23) and 29% (6/21), respectively (p > 0.30). Evaluation of tumor response at 40 Gy was an important indicator of local control for N0 oropharynx carcinoma.
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