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  • Title: Selective IgM deficiency in a patient with Hashimoto's disease.
    Author: Kimura S, Tanigawa M, Nakahashi Y, Inoue M, Yamamura Y, Kato H, Sugino S, Kondo M.
    Journal: Intern Med; 1993 Apr; 32(4):302-7. PubMed ID: 8358120.
    Abstract:
    A 70-year-old man with Hashimoto's disease had selective IgM deficiency, while other immunoglobulin levels were normal. In vitro mixing experiments were carried out in which B cells and T cells from the patient and from a healthy control donor were co-cultured in the presence of pokeweed mitogen, in order to investigate the etiology of IgM hypoproduction. The results indicated that the patient had B-cell dysfunction, involving the impairment of B-cell differentiation. In addition, both IgG of the healthy control donor and thyroid hormone may play important roles in the pathogenesis of this case.
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