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  • Title: Better effect of methotrexate on C-reactive protein during daily compared to weekly treatment in rheumatoid arthritis.
    Author: Seideman P.
    Journal: Clin Rheumatol; 1993 Jun; 12(2):210-3. PubMed ID: 8358980.
    Abstract:
    Treatment with methotrexate (MTX) is well established in rheumatoid arthritis (RA), but dosing remains arbitrary as studies on the effect of different dosing schedules are lacking. In a randomised crossover design of 20 patients with RA, the effect of low (2.5mg) oral daily doses of MTX (15 mg weekly) was compared to intermittent weekly dosing (15 mg). C-reactive protein (CRP) values were lower and more stable on daily dosing compared to the significant (p < 0.05) changes in CRP observed during treatment with the same weekly dose. It may be postulated that nonresponders or patients with dose-dependent side effects may have clinical advantage from daily MTX dosing if hepatotoxicity and other side effects are not increased.
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