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  • Title: Distribution of B lymphocytes in nonsuppurative cholangitis in primary biliary cirrhosis.
    Author: Nakanuma Y.
    Journal: Hepatology; 1993 Sep; 18(3):570-5. PubMed ID: 8359797.
    Abstract:
    Primary biliary cirrhosis is characterized by the immune-mediated, nonsuppurative destruction of intrahepatic small bile ducts, with significant T-cell involvement. To date, B cells in livers of primary biliary cirrhosis patients have been ignored in immunopathological evaluations of nonsuppurative cholangitis. This study aimed to correlate the distribution of activated T and B cells with the histopathology of nonsuppurative cholangitis in primary biliary cirrhosis, with emphasis on B cell infiltration. The distribution of activated T and B cells and the histopathology in primary biliary cirrhosis were heterogeneous in bile ducts showing nonsuppurative cholangitis; they were also heterogeneous in various parts of a given bile duct. Although activated T cells were significantly involved in the occurrence of nonsuppurative cholangitis, B cell-predominant reaction or cholangitis and B-cell infiltration into the biliary epithelial layer were also prominent in some nonsuppurative cholangitis. Many bile ducts with nonsuppurative cholangitis of various histological types showed intermixed activated T- and B-cell infiltration. These findings indicate that immune mechanism(s) involving B cells and, probably, humoral immunity are at work in the occurrence of nonsuppurative cholangitis and the destruction of bile ducts in primary biliary cirrhosis. Cell-to-cell interactions of activated T and B cells should therefore be evaluated in livers of patients with primary biliary cirrhosis.
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