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  • Title: [Anti-Tja (PP1Pk) isoimmunization. A case, a review of the literature].
    Author: Haentjens-Verbeke K, Dufour P, Vinatier D, Bernardi C, Fonteyne G, Monnier JC, Mannessier L.
    Journal: J Gynecol Obstet Biol Reprod (Paris); 1993; 22(4):393-7. PubMed ID: 8360439.
    Abstract:
    AIM: A review of the literature concerning the very rare anti-PP1Pk isoimmunisation with a personal case. CLINICAL MATERIAL: Anti-PP1k antibody gives rise to the high risk of abortion in the first and the second trimester (in a different series the risk is 50-70%). A 19-year-old patient who had this antibody was helped by a plasmaphoresis repeatedly between the 6th and the 25th week of pregnancy. Cordocentesis was carried out to estimate fetal haemoglobin from the 25th week onwards. A set caesarean section was carried out at 36 weeks because of intrauterine growth retardation and the development of fetal anaemia. DISCUSSION: The authors suggest research based on the known immunohaematological factors concerned with this isoimmunisation and on the main treatments available (plasmaphoresis, cordocentesis, and delivery at a set time). CONCLUSION: Until now there have been very few cases and only four similar cases to ours have been reported in the literature. That is why it is so difficult to suggest a well defined strategy for treating these patients.
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