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  • Title: Collagen breakdown and nitrogen dioxide inhalation.
    Author: Hatton DV, Leach CS, Nicogossian AE.
    Journal: Arch Environ Health; 1977; 32(1):33-6. PubMed ID: 836084.
    Abstract:
    Measurements of urinary hydroxylysine glycosides indicate that considerable collagen degradation occurred during the reentry into the earth's atmosphere of the American astronauts of the Apollo-Soyuz mission. Since the crew accidentally inhaled nitrogen dioxide, a recognized pulmonary irritant, and showed clinical and roentgenographic signs of diffuse chemical pneumonitis, it is likely that collagen degradation occurred in the pulmonary parenchyma.
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