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  • Title: Prednisolone enhances myogenesis and dystrophin-related protein in skeletal muscle cell cultures from mdx mouse.
    Author: Passaquin AC, Metzinger L, Léger JJ, Warter JM, Poindron P.
    Journal: J Neurosci Res; 1993 Jul 01; 35(4):363-72. PubMed ID: 8360945.
    Abstract:
    The differentiation of skeletal muscle cells from mdx mice which lack dystrophin expression was examined after glucocorticoid treatment, namely alpha-methylprednisolone (PDN). Primary skeletal muscle cell cultures were established from newborn mdx, congenic C57BL/10, and allogenic BALB/C mice. We show that PDN promotes the myogenesis of both mdx- and control mice-derived cultures as determined by 1) the number of myotubes, 2) acetylcholine receptors, and 3) dystrophin and dystrophin-related protein levels. These results support the hypothesis that PDN could enhance the myogenesis of satellite cells and increase dystrophin-related protein expression in DMD treated patients.
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