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  • Title: [Dynamic changes in polymorphonuclear cell elastase-alpha 1 protease inhibitor complex, a stress marker, in various pulmonary diseases].
    Author: Ishizaki T, Ohnishi T, Sakai T.
    Journal: Rinsho Byori; 1993 Feb; 41(2):147-53. PubMed ID: 8361016.
    Abstract:
    Polymorphonuclear cell elastase-alpha 1 protease inhibitor complex (PMN elastase-alpha 1 PI complex), which increased in peripheral venous blood during many inflammatory diseases, showed significant transpulmonary difference (ie. mixed venous blood < arterial blood, p < 0.05) in patients with pulmonary disorders (N = 64) but not in those with nonpulmonary disorders (N = 15). Further, PMN elastase-alpha 1 PI complex exhibited higher values in arterial blood than in peripheral venous blood (p < 0.01). Taken together, this evidence suggests intrapulmonary production of PMN elastase-alpha 1 PI complex and suggests potential lung damage due to released PMN elastase. Increased and sustained elevated levels of PMN elastase-alpha 1 PI complex in acute respiratory failure with/without adult respiratory distress syndrome showed resistance to intensive medication suggesting that PMN elastase may be a good prognostic marker.
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