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  • Title: Near infrared spectroscopy (NIRS): a new tool to study hemodynamic changes during activation of brain function in human adults.
    Author: Villringer A, Planck J, Hock C, Schleinkofer L, Dirnagl U.
    Journal: Neurosci Lett; 1993 May 14; 154(1-2):101-4. PubMed ID: 8361619.
    Abstract:
    In healthy human adults, cerebral concentrations of oxygenated hemoglobin ([HbO2]) and deoxygenated hemoglobin ([HbR]) were assessed during brain activation using near infrared spectroscopy (NIRS). Measurements were made either in the frontal cortex (n = 10) during performance of cognitive tasks or in the occipital cortex (n = 6) during visual stimulation (flash-light exposure, picture observation). The typical findings during brain activation were an increase in [HbO2] and a decrease in [HbR]. We demonstrate that these findings are not due to alterations in skin blood flow. NIRS is a simple bedside technique for the assessment of hemodynamic alterations accompanying brain activation.
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