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  • Title: [Severe bone malformations in fetal valproic acid disease].
    Author: Lorenzo Sanz G, Serna Saugar C, Quintana Castilla A, Lozano Giménez C, Aparicio Meix JM.
    Journal: An Esp Pediatr; 1993 Jul; 39(1):19-21. PubMed ID: 8363144.
    Abstract:
    The dysmorphogenic and teratogenic effects of valproic acid, when administered to pregnant women, have been noted in several reports. We report the case of a 3-month-old infant with multiple congenital anomalies, including severe skeletal malformations, congenital heart defect and facial dysmorphism, whose mother was treated with valproic acid (1000 mg/day) throughout the pregnancy. This is the second published case reporting major skeletal malformations and supports the possible teratogenic effects of valproic acid.
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