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  • Title: Failure of 3,4-diaminopyridine to reverse conduction block in inflammatory demyelinating neuropathies.
    Author: Bergin PS, Miller DH, Hirsch NP, Murray NM.
    Journal: Ann Neurol; 1993 Sep; 34(3):406-9. PubMed ID: 8363359.
    Abstract:
    3,4-Diaminopyridine was administered to 6 patients with inflammatory demyelinating neuropathies in whom partial conduction block was demonstrable. Four had Guillain-Barré syndrome and 2 had chronic inflammatory demyelinating neuropathy. Nerve conduction studies were performed before the administration of a single oral dose of 3,4-diaminopyridine, and at regular intervals thereafter. Neither resolution of conduction block nor clinical benefit were seen.
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