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  • Title: [Transdermal application of 10% lidocaine-gel for management of pain associated with herpes zoster].
    Author: Shimoda O, Kano T, Takaki M, Tashima T, Tashiro M, Ikuta Y, Morioka T, Nakano M, Mishima M.
    Journal: Masui; 1993 Aug; 42(8):1171-6. PubMed ID: 8366557.
    Abstract:
    We have developed transdermally applicable 10% lidocaine aqueous gel containing an absorption promoter and applied it for 15 patients suffering from severe pain in acute or subacute phase of herpes zoster. The patients, consisting of 7 males and 8 females with a mean age 58.5 +/- 13.0 (SD) yrs, had skin eruptions of herpes zoster for the past 2 months. Lidocaine-gel was applied locally to the diseased skin with or without an occlusive dressing. In 14 of the 15 patients (93%), a remarkable reduction of pain (below 10% of pretreatment level) was obtained after 9.9 +/- 5.6 (SD) times of lidocaine-gel treatments. There was no adverse systemic reactions or local skin damages. None of them developed post-herpetic neuralgia. The lidocaine-gel treatment appears to be very useful for reduction of pain associated with acute or subacute phase of herpes zoster.
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