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  • Title: [Cryptococcosis of the central nervous system].
    Author: Calderón E, Cob C, González N, Hernández M, Martínez E.
    Journal: Bol Med Hosp Infant Mex; 1977; 34(1):83-93. PubMed ID: 836724.
    Abstract:
    The steps for diagnosis and treatment and the clinical course followed in three patients with Cryptococcus meningitidis are discussed. One of them was treated with 5-flurocytosine alone. Two consecutive patients were treated with a combination of 5-flurocytosine and amphotericin B. The objectives of the study were: a) to achieve a therapeutic response better than that which might be obtained with either drug alone, b) to use lower doses of 5-fluorocytosine and amphotericin B in order to reduce toxicity, c) to extend treatment only for a period of four weeks, thus decreasing the period of hospitalization. None of the patients has relapsed. A shorter time of hospitalization and reduction in toxicity, suggests that combined therapy is a safe and effective alternative to other regimens.
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