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  • Title: [Peptidergic mechanisms in the parasympathetic regulation of the heart rate].
    Author: Osadchiĭ OE, Pokrovskiĭ VM.
    Journal: Usp Fiziol Nauk; 1993; 24(3):71-88. PubMed ID: 8368001.
    Abstract:
    Besides the classic cholinergic and adrenergic mechanisms, the regulatory peptides involve in regulating the cardiac rhythm. The localization of the latter in neurons of intracardiac nervous system as well as the possibility of releasing the regulatory peptides, individually or in combination with the classic mediators, during extracardiac nerves is found. The regulatory peptides are capable of affecting the heart autonomy directly or in a mediated way via modulation of the vegetative effects. The paper contains data on the cardiotropic activity of various peptides and direction of their effects relating to parasympathetic control a cardiac rhythm. There is a suggestion concerning an existence of different ways of realization of peptidergic vagotropic effect that presupposes not only variation of severity of parasympathetic chronotropic effect but also a change in its functional organization.
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