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  • Title: [Chronic lipogranuloma (paraffin granuloma) of the eyelids and orbits after endonasal paranasal sinus operation].
    Author: Geiger K, Witschel H, Büttner C.
    Journal: Laryngorhinootologie; 1993 Jul; 72(7):356-60. PubMed ID: 8369091.
    Abstract:
    During the last five years 10 patients received surgical treatment in our eye clinic for tumours of the eyelids and the orbit that had developed after endonasal sinus surgery. In most patients the first signs of lid or orbital involvement had occurred 4 weeks after ENT surgery and after a unilateral or bilateral postoperative haematoma had subsided. The histological examination of the surgical specimens showed chronic sclerosing lipogranuloma containing large vacuoles surrounded by epithelioid and giant cells, typical of a so-called paraffin granuloma. MR-spectroscopy detected high concentrations of paraffin in the specimens of 3 patients. Since paraffin is a constituent of many ointments, we assume that the granulomatous reaction was elicited by the ointment tampons routinely applied to the wound area following sinus surgery. The bleeding acted as a vehicle to distribute the paraffin into the surrounding tissues.
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