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  • Title: Nature of histamine receptors concerned in capillary permeability.
    Author: Bhargava KP, Nath R, Palit G.
    Journal: Br J Pharmacol; 1977 Feb; 59(2):349-51. PubMed ID: 837022.
    Abstract:
    1 Histamine and 2-methyl-histamine (H1-receptor agonist) caused dose-dependent increases in capillary permeability in albino mice, but 4-methyl-histamine (H2-receptor agonist) caused no significant increase. 2 Mepyramine (H1-receptor antagonist) blocked the histamine-induced increase in capillary permeability whereas burimamide (H2-receptor antagonist) produced no significant blockade of the histamine-response. 3 Combined mepyramine and burimamide pretreatment did not give any significantly greater protection than mepyramine alone. 4 The results indicate involvement of the H1-receptors in histamine-induced increase in capillary permeability.
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