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  • Title: Suicide substrate reaction--diffusion equations: varying the source.
    Author: Burke MA, Maini PK, Murray JD.
    Journal: IMA J Math Appl Med Biol; 1993; 10(2):97-114. PubMed ID: 8370995.
    Abstract:
    The suicide substrate reaction is a model for certain enzyme-inhibiting drugs. This reaction system is examined assuming that the substrate diffuses freely while the enzyme remains fixed. Two sets of initial and boundary conditions are examined: one modelling an instantaneous point source, akin to an injection of substrate, the other, a continuous point source, akin to a continuing influx, or intravenous drip, of substrate. The quasi-steady-state assumption is applied to obtain analytical solutions for a limited parameter space. Finally, further applications of numerical and analytical experimentation on pharmaceutical mechanisms are described.
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