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  • Title: BCG vaccination protects against leprosy in Venezuela: a case-control study.
    Author: Convit J, Smith PG, Zuniga M, Sampson C, Ulrich M, Plata JA, Silva J, Molina J, Salgado A.
    Journal: Int J Lepr Other Mycobact Dis; 1993 Jun; 61(2):185-91. PubMed ID: 8371026.
    Abstract:
    A total of 64,570 household and other close contacts of about 2000 leprosy cases were screened for eligibility for entry into a trial of a new leprosy vaccine. The screening procedure included a clinical examination for leprosy and for the presence of BCG and lepromin scars. Ninety-five new cases of leprosy were identified, and the prevalence of BCG and lepromin scars among them was compared with similar data from matched controls selected from among those with no evidence of leprosy. The difference in the prevalence of BCG scars in the two groups was used to estimate the protection against leprosy conferred by BCG vaccination. One or more BCG scars was associated with a protective efficacy of 56% (95% confidence limits 27% to 74%). There was a trend of increasing protection with four or more BCG scars, but this was not statistically significant. There was no evidence that the efficacy of BCG varied with age or according to whether or not the contact lived in the same household as a case. The protective effect was significantly higher among males, and was significantly greater for multibacillary than for paucibacillary leprosy.
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