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  • Title: Morphine, naloxone and the responses of medial thalamic neurones of the cat.
    Author: Duggan AW, Hall JG.
    Journal: Brain Res; 1977 Feb 11; 122(1):49-57. PubMed ID: 837223.
    Abstract:
    Administered electrophoretically morphine depressed the firing of medial thalamic neurones. This effect was not antagonized by naloxone which itself was a depressant. A long lasting increase in sensitivity to L-glutamate followed ejection of both morphine and naloxone. Intravenous morphine, 0.5-1.5 mg/kg, had inconstant effects on spontaneous firing that evoked by electrical stimulation of the forepaws but in 7 of 10 experiments reduced the sensitivity of neurones to L-glutamate. This effect was reversed in all cases by intravenous naloxone, 0.3 mg/kg
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