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  • Title: The use of cryosurgery in the treatment of low and medium grade chondrosarcoma. A preliminary report.
    Author: Marcove RC, Stovell PB, Huvos AG, Bullough PG.
    Journal: Clin Orthop Relat Res; 1977; (122):147-56. PubMed ID: 837601.
    Abstract:
    Eighteen chondrosarcoma (Grade I and Grade II) have been treated with cryosurgery. One patient subsequently developed a metastasis; three later had to have an en bloc resection (in two of these there was no tumor in the specimen) and three underwent amputation (one of these had tumor in the specimen). In general, cryosurgery for low grade chondrosarcoma is encouraging as long as the limb is protected postoperatively from fracture -- using various orthopedic appliances to allow bone regeneration (i.e. ischial weight bearing brace). Other complications such as nerve paralysis have been transient. One air embolis death occurred (in another disease) where the exit of nitrogen gas was blocked. This is preventable by allowing free exit of gas from the bone. Approximately 500 cases of primary bone have been treated with cryosurgery as of this date; long term follow-up results will be reported later.
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