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  • Title: Morphological changes of Candida albicans induced by BMY-28864, a highly water-soluble pradimicin derivative.
    Author: Numata K, Ueki T, Naito N, Yamada N, Kamasawa N, Oki T, Osumi M.
    Journal: J Electron Microsc (Tokyo); 1993 Jun; 42(3):147-55. PubMed ID: 8376921.
    Abstract:
    The time course of BMY-28864-dependent morphological changes in Candida albicans A9540 was studied by electron microscopy. Scanning electron microscopy revealed that BMY-28864 often induced cell surface deformations such as abnormal swelling and bulging around budding sites and bud scars. The cell membrane damage was visualized by freeze-fracturing technique as deep pit-like invaginations. Transmission electron microscopy with thin-sectioned specimens also demonstrated that BMY-28864 induced cell membrane invaginations together with cell membrane detachment from the cell wall, nuclear membrane fragmentation and mitochondrial aberration. Statistical sequence analysis of the prominent BMY-28864-dependent morphological changes of the yeast cells led to the conclusion that BMY-28864 first attacked the cell membrane and then caused disintegration of other intracytoplasmic organelles, resulting in the lethal effect.
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