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  • Title: A Saccharomyces cerevisiae cyclophilin resident in the endoplasmic reticulum.
    Author: Frigerio G, Pelham HR.
    Journal: J Mol Biol; 1993 Sep 05; 233(1):183-8. PubMed ID: 8377189.
    Abstract:
    Cyclophilins are cyclosporin A sensitive peptidyl-prolyl cis-trans isomerases found in the cytoplasm of a wide range of species from Escherichia coli to man. Cyclophilin homologues are translocated into mitochondria, the endoplasmic reticulum and the bacterial periplasmic space. Here, the nucleotide sequence of a non-essential fifth Saccharomyces cerevisiae cyclophilin homologue encoded by chromosome XII is presented. As expected from its hydrophobic signal sequence and a hydrophilic carboxy terminus ending in the tetrapeptide HDEL, epitope-tagged cyclophilin D was found associated with the endoplasmic reticulum.
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