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  • Title: Expression of the cholecystokinin gene in organotypic slice cultures of immature rat somatosensory cortex.
    Author: Olenik C, Heimrich B, Meyer DK.
    Journal: Neurosci Lett; 1993 Jun 11; 155(2):204-7. PubMed ID: 8377950.
    Abstract:
    The preprocholecystokinin gene is expressed in a subpopulation of cortical interneurons containing gamma-aminobutyric acid. Slices of neonatal rat cortex were cultivated for 12 +/- 2 days and examined for the presence and distribution of these neurons by in situ hybridization and immunocytochemistry. Like in situ, two layers of preprocholecystokinin-mRNA-expressing cells were present. Immunopositive fibers formed a dense network and established symmetric contacts on dendritic shafts and spines. It is concluded that cholecystokinin-expressing interneurons survive in cultured slices of rat cerebral cortex. These organotypic cultures may be useful to study the cellular interactions which regulate neuronal cholecystokinin expression.
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