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  • Title: Long cellular repeats flanking a defective HTLV-I provirus: implication for site-targeted integration.
    Author: Kubota S, Furuta R, Maki M, Siomi H, Hatanaka M.
    Journal: Oncogene; 1993 Oct; 8(10):2873-7. PubMed ID: 8378096.
    Abstract:
    Retroviruses generally integrate as proviruses which are flanked by long-terminal repeats (LTRs) on both 5' and 3' ends. Since these LTRs are required for the efficient integration mediated by the viral integrase, it is believed that defective proviruses with a single LTR are normally formed by deletion after integration. However, we found no deletion of cellular sequences around the integration site of such a defective HTLV-1. Rather, we identified 99 bp-long direct repeats adjacent to both ends of the defective provirus. The repeated cellular sequences contained a potential poly(A) signal followed by a retroviral primer-binding-site-like sequence. The presence of the direct repeats of cellular sequences can be explained by the integration of the defective virus through homologous recombination between cellular and viral read-through sequences.
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