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  • Title: [Neonatal respiratory distress syndrome treated with a natural surfactant. The Norwegian Curosurf study].
    Author: Saugstad OD, Danielsen K, Grønn M, Holt J, Meberg A, Silberg IE, Okland O.
    Journal: Tidsskr Nor Laegeforen; 1993 Aug 20; 113(19):2389-93. PubMed ID: 8378900.
    Abstract:
    43 Norwegian premature infants with respiratory distress syndrome were randomized to receive either a high dose (initial dose 200 mg/kg) or a low dose (initial dose 100 mg/kg) of natural porcine surfactant (Curosurf). In the high dose group, up to five doses of surfactant could be given compared with three in the low dose group. In the high dose group, oxygen requirement was significantly lower during the first 36 hours after surfactant was administered than the requirement in the low dose group. There was no difference in outcome between the high and low dose groups. Outcome was poor for babies with birthweight < 750 gram or gestational age < 26 weeks, in spite of an initial favourable surfactant response in several of them. We conclude that the initial dose of Curosurf should be 100 mg/kg and two more doses can be given if necessary.
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