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  • Title: [Correlation of lipid peroxidation intensity and insulin reception in adipocytes].
    Author: Ivanov VV, Stennikova MP.
    Journal: Vopr Med Khim; 1993; 39(4):23-5. PubMed ID: 8379107.
    Abstract:
    Influence of prooxidants (cumene hydroperoxide and Fe2+) on insulin reception by adipocytes was studied in experimental conditions. Cumene hydroperoxide (10(-7) M) in the presence of Fe2+ (0.2 mM) increased the specific binding of the hormone. The higher concentrations (10(-6)-10(-3) M) of the prooxidant resulted in significant accumulation of malonic dialdehyde and inhibited insulin binding by fat tissue cells. The inhibition of insulin specific binding was shown to occur due to a decrease in the content of insulin receptors as well as in the rate of their affinity to the hormone.
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