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  • Title: Cohort study of rotavirus serotype patterns in symptomatic and asymptomatic infections in Mexican children.
    Author: Raúl Velázquez F, Calva JJ, Lourdes Guerrero M, Mass D, Glass RI, Pickering LK, Ruiz-Palacios GM.
    Journal: Pediatr Infect Dis J; 1993 Jan; 12(1):54-61. PubMed ID: 8380235.
    Abstract:
    A cohort of 200 Mexican children from a low income periurban community was monitored from birth to the age of 2 years to determine the serotype-specific incidence, morbidity and seasonal pattern of symptomatic and asymptomatic human rotavirus (HRV) infections. A total of 177 HRV infections occurred in 134 (67%) children; 50% of these infections were asymptomatic. The incidence of all HRV infections was 0.6 episode/child year and was inversely related to age (r = -0.93; P < 0.01). The incidence of HRV-associated diarrhea was 0.3 episode/child year, with the highest frequency and severity occurring in infants between 4 and 6 months of age. HRV infections were more frequent each autumn, with a changing sequential pattern of predominant serotypes. Overall serotype 3 (34%) was the most frequent, followed by serotypes 1 (16%), 2 (15%) and 4 (6%). The 4 serotypes were associated with a similar risk for diarrhea and severity of diarrhea. In 23 (26%) HRV diarrhea-associated infections, an additional enteropathogen was identified; these mixed infections were more frequent in older children (chi square, 4.45; P < 0.05) but were not more severe (chi square, 0.02; P > 0.05). Our data indicate that HRV infections were common early in life, seasonal, frequently asymptomatic and caused by a variety of serotypes, none of which was a risk factor for diarrhea or severity of diarrhea.
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