These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Mechanism of T-cell suppression in tolerance to HGG: arguments in favor of a T-cell-T-cell interaction.
    Author: Chaouat G.
    Journal: Ann Immunol (Paris); 1978; 129 C(5):685-93. PubMed ID: 83811.
    Abstract:
    The specific soluble factor from suppressor T cells of CBA mice rendered tolerant to human gammaglobulin was further investigated. Immunochemical analysis proved the low zone tolerance (LZT) factor to be similar as the one described in high zone (HZT), e. g. absorbed by anti-Iak or IGG but not anti-HGG or anti-IgG. Molecular weight was ascribed as 45--55,000 by Sephadex chromatography and "Amicon" ultrafiltration. The HZT factor acts only if administered early after challenge, and on T cell as judged by double transfer experiments, suggesting impairment of early T-cell function (helper?) by suppressor cells.
    [Abstract] [Full Text] [Related] [New Search]