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  • Title: Cyclic adenosine 3',5'-monophosphate, a second messenger in interleukin-1 mediated K562 cytostasis.
    Author: Weitzmann MN, Savage N.
    Journal: Biochem Biophys Res Commun; 1993 Jan 29; 190(2):564-70. PubMed ID: 8381280.
    Abstract:
    This study evaluates intracellular cAMP concentrations, in interleukin-1 (IL-1) mediated cytostasis of K562 cells. Dibutyryl-cAMP, forskolin, staurosporine and phorbol 12-myristate 13-acetate were all found to mimic the cytostatic action of IL-1 on K562 cells. IL-1 was found to elicit a dose-dependent rise in adenyl cyclase activity in isolated K562 membranes, as well as increasing cAMP concentrations in whole cells. cAMP concentrations were found to peak within 3 minutes of IL-1 stimulation. A 27-29% reduction in proliferative activity elicited by IL-1, forskolin and staurosporine, correlated with a 6 fold increase in adenyl cyclase activity, in each case.
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