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  • Title: Trisomy 8 as a recurrent clonal abnormality in breast cancer?
    Author: Bullerdiek J, Leuschner E, Taquia E, Bonk U, Bartnitzke S.
    Journal: Cancer Genet Cytogenet; 1993 Jan; 65(1):64-7. PubMed ID: 8381713.
    Abstract:
    The results of cytogenetic investigations on one benign and 15 malignant breast tumors are described. Trisomy 7, 8, 18, and 21 and monosomy X occurred as clonal numerical aberrations, and inv(7)(q21q31) and t(4;12)(q21;p13) occurred as clonal structural aberrations. Only trisomy 8 was a recurrent karyotypic abnormality, however. Thus, we assumed that trisomy 8 as an early genetic change characterizes a subtype of ductal breast carcinomas.
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