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  • Title: [Therapeutic strategy of newly developing medicines for disseminated intravascular coagulation--activated protein C and thrombomodulin].
    Author: Maruyama I.
    Journal: Nihon Rinsho; 1993 Jan; 51(1):99-106. PubMed ID: 8381887.
    Abstract:
    Thrombomodulin-protein C system plays a very important role for the blood fluidity converting thrombin from a procoagulant protease to an anticoagulant and degrading activated factors Va and V III a. By their properties, both thrombomodulin and protein C may be expected for therapeutic medicines in DIC and some thromboembolic disorders. We reviewed and evaluated the probability of activated protein C and thrombomodulin for DIC treatment. Both appeared to be a very expectant for DIC medicine based on the preliminary clinical or experimental trials. Activated protein C is now under clinical trial in DIC. Recombinant thrombomodulin is also going to start its clinical trial in very near future.
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