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  • Title: Crystals of hemagglutinin-neuraminidase of parainfluenza virus contain triple-stranded helices.
    Author: Murti KG, Takimoto T, Laver WG, Portner A.
    Journal: Proc Natl Acad Sci U S A; 1993 Feb 15; 90(4):1523-5. PubMed ID: 8381970.
    Abstract:
    When purified dimers of hemagglutinin-neuraminidase molecules released by protease digestion from three strains of human parainfluenza virus 1 were used in crystallization trials, long thin needle crystals formed. Electron microscopic analysis of these needle crystals revealed that they are composed of stacks of triple-stranded helices with each strand of the helix made up of subunits of hemagglutinin-neuraminidase. To our knowledge, this is the first direct demonstration of the assembly of protein subunits into large triple-stranded helices. An understanding of the organization of these triple helices may shed light on the structural properties of the hemagglutinin-neuraminidase molecules that cause them to form these helices.
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