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  • Title: An inhibitor of inositol-phospholipid-specific phospholipase C.
    Author: Ogawara H, Higashi K, Manita S, Hidaka M, Kato H, Takenawa T.
    Journal: Biochim Biophys Acta; 1993 Feb 17; 1175(3):289-92. PubMed ID: 8382082.
    Abstract:
    Q12713 substance, a cyclic peptide from Actinomadura spp., strongly inhibited the enzyme activity of phosphatidylinositol-4,5-bisphosphate-specific phospholipase C (PIP2-PLC) but scarcely inhibited other phospholipases. Kinetic analysis demonstrated that the inhibition of PIP2-PLC activity was competitive with respect to phosphatidylinositol 4,5-bisphosphate. Calcium and magnesium ions had no significant effect on the inhibitory activity. On the contrary, potassium or rubidium ion was essential for the inhibitory activity. Furthermore, NaF and AlCl3-stimulated increase of phosphoinositides was decreased by Q12713 in the cultured 3T3 cells.
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