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  • Title: Gonadal dysgerminoma-seminoma associated with severe hypercalcemia.
    Author: Bakri YN, Akhtar M.
    Journal: Acta Obstet Gynecol Scand; 1993 Jan; 72(1):57-9. PubMed ID: 8382437.
    Abstract:
    A case is reported, of a 25-year-old phenotypic female, karyotypic male patient with metastatic gonadal dysgerminoma-seminoma and severe hypercalcemic paraneoplastic syndrome. Patient manifested normal female external genitalia, vagina, uterus, and fallopian tubes but with 46 XY karyotype. Adnexal gonads were calcified. External beam radiation therapy resolved the hypercalcemic state. Exploratory laparotomy after irradiation revealed gonadoblastoma originating from dysgenetic gonads.
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