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  • Title: Properties and functions of scatter factor/hepatocyte growth factor and its receptor c-Met.
    Author: Weidner KM, Hartmann G, Sachs M, Birchmeier W.
    Journal: Am J Respir Cell Mol Biol; 1993 Mar; 8(3):229-37. PubMed ID: 8383506.
    Abstract:
    Scatter factor (SF), a cell motility factor with a multimodular structure, is identical to hepatocyte growth factor (HGF), a potent mitogen of various cell types. The receptor for SF/HGF has recently been identified as the c-Met proto-oncogene product, a transmembrane receptor tyrosine kinase. Depending on the target cells and culture conditions, SF/HGF has several distinct activities in vitro, i.e., it induces cell motility, proliferation, invasiveness, tubular morphogenesis, angiogenesis, or cytotoxicity. In vivo, SF/HGF might be involved in tissue regeneration, tumor progression, and embryological processes.
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