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  • Title: Erythrocyte Na/K flux ratio in relation to sodium intake and a family history of essential hypertension in normotensive children.
    Author: Uchiyama M, Satokata I.
    Journal: J Hum Hypertens; 1993 Feb; 7(1):47-51. PubMed ID: 8383770.
    Abstract:
    Erythrocyte Na/K flux ratio was examined in relation to a family history of essential hypertension (FH-HT) and plasma and urine electrolytes in 84 normotensive children (13-15 yrs old), and in relation to sodium intake in six children with acute glomerulonephritis or IgA nephropathy who had normal renal function (6-13 yrs old). Erythrocyte Na/K flux ratio was significantly lower in children with a family history of essential hypertension than in those without. Plasma and urine electrolytes (Na and K) showed no significant differences between children with and without a family history of essential hypertension, although erythrocyte Na/K flux ratio was negatively correlated with serum K level in the whole group. Furthermore, erythrocyte Na/K flux ratio was unchanged before and after the restriction of sodium intake in children with nephropathy. These findings suggest that the erythrocyte Na/K flux ratio may be suppressed in normotensive children with a family history of essential hypertension as previously reported in hypertensive adults, and that plasma K level should be considered first when evaluating the erythrocyte Na/K flux ratio.
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