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  • Title: Prenatal diagnosis of cytomegalovirus (CMV) infection: a preliminary report.
    Author: Hogge WA, Buffone GJ, Hogge JS.
    Journal: Prenat Diagn; 1993 Feb; 13(2):131-6. PubMed ID: 8385332.
    Abstract:
    Eight patients were referred for prenatal diagnosis for suspected fetal cytomegalovirus infection (CMV): six for documented first-trimester infection and two for abnormal ultrasound evaluation suggestive of fetal infection. Three methods of diagnosis were employed: (1) amniotic fluid viral cultures and CMV-specific IgM in fetal serum; (2) amniotic fluid cultures and detection by polymerase chain reaction amplification of CMV-specific DNA in chorionic villi; and (3) detection of CMV-specific DNA in villus samples only. Amniotic fluid cultures detected all cases of infection, but CMV-specific IgM was not a reliable indicator of infection in any case. DNA analysis correlated well with both culture results and clinical outcome.
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