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  • Title: [X-chromosomal recessively inherited lymphoproliferative syndrome. An analysis of EBV-induced immune deficiency].
    Author: Kammermeier-Schmidt U, Weiss M, Belohradsky BH.
    Journal: Monatsschr Kinderheilkd; 1993 Mar; 141(3):201-6. PubMed ID: 8386321.
    Abstract:
    In recent years an increasing number of reports have described Epstein-Barr virus (EBV)-induced lymphoproliferative disease, or portrayed EBV as a cofactor in lymphoproliferative diseases (e.g. Hodgkin's disease, Burkitt's lymphoma and nasopharyngeal carcinoma), in the presence of congenital or acquired immune defects. Improved molecular biological and immunological techniques now permit detailed investigation of EBV itself and of the immune system's reaction to EBV infection. Our analysis of X-chromosome-transmitted lymphoproliferative syndrome (XLP), an immune defect that occurs after EBV infection, depicts the whole spectrum of symptoms of EBV-associated diseases, explains various theories regarding pathogenesis, and discusses diagnostic and therapeutic measures.
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