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  • Title: Are leukotrienes or PAF involved in hyperbaric oxygen toxicity?
    Author: Lin Y, Jamieson D.
    Journal: Agents Actions; 1993 Jan; 38(1-2):66-75. PubMed ID: 8386902.
    Abstract:
    Several very selective leukotriene inhibitors, and a PAF inhibitor, suitable for in vivo use, have been tested for their effects on hyperbaric oxygen toxicity. The leukotriene D4 inhibitor, L660771, and the 5-lipoxygenase pathway inhibitor L663536, failed to affect convulsions or lung damage induced by hyperbaric oxygen (pressure range 515-615 kPa) in either rats or mice. The specific PAF antagonist L659989 showed marginal protection against hyperoxic convulsions and did not alter pulmonary damage. The specific LTB4 antagonist SC-41930 was very effective in inhibiting hyperbaric oxygen-induced convulsions in both rats and mice. SC-41930 also very significantly protected rats against pulmonary oxygen toxicity, but had only marginally significant effects on pulmonary protection in mice.
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