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  • Title: Kinetics of relaxation responses to vasorelaxants in intact and adventitia- and endothelium-denuded isolated rabbit thoracic aorta.
    Author: Wiener HL, Sehba FA.
    Journal: Gen Pharmacol; 1993 Jan; 24(1):43-8. PubMed ID: 8387046.
    Abstract:
    1. Although the relaxation responses to 5'-N-ethylcarboxamidoadenosine and sodium nitroprusside were stable, the relaxation response to isoproterenol partially desensitized as was observed by the partial regaining of tissue tension. 2. The apparent rate constant for relaxation by all three vasorelaxants was decreased in the presence of the adventitia and endothelium. 3. The magnitude of the relaxation responses for all three vasorelaxants and the apparent rate constant for isoproterenol desensitization were similar in intact and denuded tissues.
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